2017

Deconstruction of the Ras switching cycle through saturation mutagenesis


Pradeep Bandaru, Neel H. Shah, Moitrayee Bhattacharyya, John P. Barton, Yasushi Kondo, Joshua C. Cofsky, Christine L. Gee, Arup K. Chakraborty, Tanja Kortemme, Rama Ranganathan, and John Kuriyan

eLife 2017;6:e27810 doi:10.7554/eLife.27810

Identification of inhibitors of the association of ZAP-70 with the T cell receptor
by high-throughput screen


Patrick R. Visperas, Christopher G. Wilson, Jonathan A. Winger, Qingrong Yan, Kevin Lin, Michelle R. Arkin, Arthur Weiss and John Kuriyan

SLAS Discov. 2017 Mar 1;22(3):324-331.
doi: 10.1177/1087057116681407. Epub 2016 Dec 13

2016

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor


Neel H. Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A. Kadlecek, Ian R. Fallahee, William P. Russ, Rama Ranganathan, Arthur Weiss and John Kuriyan

eLife 2016 Oct 4;5:e20105. doi: 10.7554/eLife.20105

Molecular basis for multimerization in the activation of the epidermal growth factor receptor


Yongjian Huang*, Shashank Bharill*, Deepti Karandur, Sean M. Peterson, Morgan Marita, Xiaojun Shi, Megan J. Kaliszewski, Adam W. Smith, Ehud Y. Isacoff and John Kuriyan

eLife 2016 Mar 28;5:e14107.
doi: 10.7554/eLife.14107.

Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II


Moitrayee Bhattacharyya*, Margaret M. Stratton*, Catherine C. Going*, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L. Gee, Tiago Barros, Howard Schulman, Evan R. Williams and John Kuriyan

eLife 2016 Mar 7;5:e13405.
doi: 10.7554/eLife.13405.

Crystal Structure of a Ube2S-Ubiquitin Conjugate


Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John Kuriyan

PLoS One 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550

2015

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220)


Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan

PLoS One 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177

Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor


Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John Kuriyan

Mol Cell Biol. 2015 Sep 1;35(17):3083-102.
doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29.
Lorenz et al 2015

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity


Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

Biochem. J. 2015, Jun 1;468(2):283-91 doi:10.1042/BJ20141492
Wang et al 2015

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate


Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan

eLife 2015 10.7554/eLife.06074
Visperas et al 2015

Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding


Patrick R. Visperas, Jonathan A. Winger, Timothy M. Horton, Neel H. Shah, Diane J. Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G. Wilson, Michelle R. Arkin, Arthur Weiss and John Kuriyan

Biochem J. 2015;465(1):149-61

2014

Stratton et al 2014

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity


Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan

eLife 2013 Jan 1;3:e01610. doi: 10.7554/eLife.01610

2013

Iwig et al 2013

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1


Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan

eLife 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813

A structural role for the PHP domain in E. coli DNA polymerase III


Tiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O'Donnell, John Kuriyan and Meindert H. Lamers

BMC Struct Biol. 2013 May 14;13:8.
doi: 10.1186/1472-6807-13-8

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation


Kate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan

Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker


Qingrong Yan, Tiago Barros, Patrick R. Visperas, Sebastian Deindl, Theresa A. Kadlecek, Arthur Weiss and John Kuriyan

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor


Nicholas F. Endres*, Rahul Das*, Adam W. Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G. Pelton, Yibing Shan, David E. Shaw, David E. Wemmer, Jay T. Groves and John Kuriyan

Cell 2013 Jan 31;152(3):543-56. doi: 10.1016/j.cell.2012

2011

How a DNA polymerase clamp loader opens a sliding clamp


Brian A. Kelch*, Debora L. Makino*, Michael O'Donnell and John Kuriyan

Science 2011 Dec 23;334(6063):1675-80. doi: 10.1126/science.1211884

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme


Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman and John Kuriyan

Cell 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2


Katherine E Wickliffe*, Sonja Lorenz*, David E. Wemmer, John Kuriyan and Michael Rape

Cell 2011 Mar 4;144(5):769-81. doi: 10.1016/j.cell.2011.01.035

2010

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation


Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John Kuriyan

Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless


Jodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci U S A.2010 Feb 23;107(8):3430-5. doi: 10.1073/pnas.0913915107

Analysis of the role of PCNA-DNA contacts during clamp loading


Randall McNally, Gregory D Bowman, Eric R Goedken, Mike O'Donnell and John Kuriyan

BMC Struct. Biol.2010 Jan 30;10:3. doi: 10.1186/1472-6807-10-3

2009

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3


Natalia Jura, Yibing Shan, Xiaoxian Cao, David Shaw and John Kuriyan

Proc Natl Acad Sci U S A.2009 Dec 22;106(51):21608-13. doi: 10.1073/pnas.0912101106

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response


Sebastian Deindl, Theresa A. Kadlecek, Xiaoxian Cao, John Kuriyan and Arthur Weiss

Proc Natl Acad Sci U S A.2010 Feb 23;107(8):3430-5. doi: 10.1073/pnas.0913915107

The tyrosine kinase Csk dimerizes through its SH3 domain


Nicholas M. Levinson, Patrick R. Visperas and John Kuriyan

PLoS One 2009 Nov 4;4(11):e7683. doi: 10.1371/journal.pone.0007683

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment


Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang and John Kuriyan

Cell 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex


Kyle R. Simonetta, Steven L. Kazmirski, Eric R. Goedken, Aaron J. Cantor, Brian A. Kelch, Randall McNally, Steven N. Seyedin, Debora L. Makino, Mike O'Donnell and John Kuriyan

Cell 2009 May 15;137(4):659-71. doi: 10.1016/j.cell.2009.03.044

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations


Markus A. Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E. Shaw, Neil P. Shah, John Kuriyan and Dustin J. Maly

Cancer Res. 2009 Mar 15;69(6):2384-92. doi: 10.1158/0008-5472.CAN-08-3953

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)


Jonathan A. Winger, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

BMC Struct Biol. 2009 Feb 24;9:7. doi: 10.1186/1472-6807-9-7

Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1


Tanya S. Freedman, Holger Sondermann, Olga Kuchment, Gregory D. Friedland, Tanja Kortemme and John Kuriyan

Structure 2009 Jan 14;17(1):41-53. doi: 10.1016/j.str.2008.11.004

2008

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase


Jonathan A. Winger, Emily R. Derbyshire, Meindert H. Lamers, Michael A. Marletta and John Kuriyan

BMC Struct Biol. 2008 Oct 7;8:42. doi: 10.1186/1472-6807-8-42

Membrane-dependent signal integration by the Ras activator Son of sevenless


Jodi Gureasko, William J. Galush, Sean Boykevisch, Holger Sondermann, Dafna Bar-Sagi, Jay T. Groves and John Kuriyan

Nat Struct Mol Biol. 2008 May;15(5):452-61. doi: 10.1038/nsmb.1418

Structural Basis for the Recognition of c-Src by Its Inactivator Csk


Nicholas M. Levinson, Markus A. Seeliger, Philip A. Cole and John Kuriyan

Cell 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051

2007

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface


Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole, and John Kuriyan

Nature 2007 Nov 29;450(7170):741-4

Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70


Sebastian Deindl, Theresa A. Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss and John Kuriyan

Cell 2007 May 18;129(4):735-46

c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty


Markus A. Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, M. Nidanie Henderson and John Kuriyan

Structure 2007 Mar;15(3):299-311

2006

Protein-protein Interactions in the Allosteric Regulation of Protein Kinases


Patricia Pellicena and John Kuriyan

Curr Opin Struct Biol. 2006 Dec;16(6):702-9

A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless


Tanya S. Freedman*, Holger Sondermann*, Gregory D. Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee and John Kuriyan

Proc Natl Acad Sci U S A 2006 Nov 7;103(45):16692-7

Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III


Meindert H. Lamers, Roxana E. Georgescu, Sang-Gyu Lee, Mike O'Donnell and John Kuriyan

Cell 2006 Sep 8;126(5):881-92

A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases


Michelle Pirruccello, Holger Sondermann, Jeffrey G. Pelton, Patricia Pellicena, André Hoelz, Jonathan Chernoff, David E. Wemmer and John Kuriyan

J Mol Biol. 2006 Aug 11;361(2):312-26

An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor


Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A. Cole and John Kuriyan

Cell 2006 Jun 16;125(6):1137-49

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain


Nicholas M. Levinson*, Olga Kuchment*, Kui Shen, Matthew A. Young, Michael Koldobskiy, Martin Karplus, Philip A. Cole and John Kuriyan

PLoS Biol. 2006 May;4(5):e144

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680


Matthew A. Young, Neil P. Shah, Luke H. Chao, Markus Seeliger, Zdravko V. Milanov, William H. Biggs, III, Daniel K. Treiber, Hitesh K. Patel, Patrick P. Zarrinkar, David J. Lockhart, Charles L. Sawyers and John Kuriyan

Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase


Bhushan Nagar, Oliver Hantschel, Markus Seeliger, Jason M. Davies, William I. Weis, Giulio Superti-Furga and John Kuriyan

Mol Cell. 2006 Mar 17;21(6):787-98

Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II


Oren S. Rosenberg, Sebastian Deindl, Luis R. Comolli, André Hoelz, Kenneth H. Downing, Angus C. Nairn and John Kuriyan

Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium


Maria A. Argiriadi, Eric R. Goedken, Irina Bruck, Mike O’Donnell and John Kuriyan

BMC Struct Biol. 2006 Jan 10;6:2

2005

Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme


Oren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung, Angus C. Nairn and John Kuriyan

Cell 2005 Dec 2;123(5):849-60

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases


Markus A. Seeliger, Matthew Young, M. Nidanie Henderson, Patricia Pellicena, David S. King, Arnold M. Falick and John Kuriyan

Protein Sci. 2005 Dec;14(12):3135-9

Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless


Holger Sondermann, Bhushan Nagar, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci U S A 2005 Nov 15;102(46):16632-7

Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen


Steven L. Kazmirski, Yanxiang Zhao, Gregory D. Bowman, Mike O’Donnell and John Kuriyan

Protein Sci. 2005 Dec;14(12):3135-9

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex


Eric R Goedken, Steven L Kazmirski, Gregory D Bowman, Mike O'Donnell and John Kuriyan

Nat Struct Mol Biol 2005 Feb;12(2):183-90

2004

Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex


Steven L. Kazmirski*, Marjetka Podobnik*, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Proc Natl Acad Sci U S A 2004 Nov 30;101(48):16750-5

Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless


Holger Sondermann*, Stephen M. Soisson*, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi and John Kuriyan

Cell 2004 Oct 29;119(3):393-405

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases


Patricia Pellicena, David S. Karow, Elizabeth M. Boon, Michael A. Marletta and John Kuriyan

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex


Gregory D. Bowman, Mike O'Donnell and John Kuriyan

Nature 2004 Jun 17;429(6993):724-30

Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding


Eric R. Goedken, Marcia Levitus, Aaron Johnson, Carlos Bustamante, Mike O’Donnell and John Kuriyan

J Mol Biol. 2004 Mar 5;336(5):1047-59

Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex


Jacqueline M. Gulbis, Steven L. Kazmirski, Jeff Finkelstein, Zvi Kelman, Mike O'Donnell and John Kuriyan

Eur J Biochem. 2004 Jan;271(2):439-49

2003

Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless


Holger Sondermann, Stephen M. Soisson, Dafna Bar-Sagi, and John Kuriyan

Structure 2003 Dec;11(12):1583-93

Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II


Andre Hoelz, Angus C. Nairn and John Kuriyan

Mol Cell. 2003 May;11(5):1241-51

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS


S. Mariana Margarit, Holger Sondermann, Brian E. Hall, Bhushan Nagar, Andre Hoelz, Michelle Pirruccello, Dafna Bar-Sagi, and John Kuriyan

Cell 2003 Mar 7;112(5):685-95

Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit


Marjetka Podobnik, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Structure 2003 Mar;11(3):253-63

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase


Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J

Cell 2003 Mar 21;112(6):859-71

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl


Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G

Cell 2003 Mar 21;112(6):845-57

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase


Xiaomin Chen, Rashna Bhandari, Uwe Vinkemeier, Focco van den Akker, James E. Darnell Jr. and John Kuriyan

Protein Sci. 2003 Feb;12(2):361-5

2002

Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and STI571


Bhushan Nagar, William Bornmann, Patricia Pellicena, Thomas Schindler, Darren Veach, W. Todd Miller, Bayard Clarkson and John Kuriyan

Cancer Res. 2002 Aug 1;62(15):4236-43

2001

The TGF Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch


Morgan Huse, Tom W. Muir, Lan Xu, Ye-Guang Chen, John Kuriyan and Joan Massagué

Mol Cell. 2001 Sep;8(3):671-82

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III


David Jeruzalmi, Olga Yurieva, Yanxiang Zhao, Matthew Young, Jelena Stewart, Manju Hingorani, Mike O'Donnell and John Kuriyan

Cell 2001 Aug 24;106(4):417-28

Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III


David Jeruzalmi, Mike O'Donnell and John Kuriyan

Cell 2001 Aug 24;106(4):429-441

Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity


Hiroto Yamaguchi, Masayuki Matsushita, Angus C. Nairn and John Kuriyan

Mol Cell 2001 May;7(5):1047-57
Young et al 2001

Dynamic Coupling Between the SH2 and SH3 Domains of C-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation


Matthew A. Young, Stefania Gonfloni, Giulio Superti-Furga, Benoit Roux and John Kuriyan

Cell 2001 Apr 6;105(1):115-26

2000

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase


Thomas Schindler, William Bornmann, Patricia Pellicena, W. Todd Miller, Bayard Clarkson and John Kuriyan

Science 2000 Sep 15;289(5486):1938-42

A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases


Marjetka Podobnik, Peter McInerney , Mike O'Donnell and John Kuriyan

J Mol Biol. 2000 Jul 7;300(2):353-62

1999

Crystal structure of an archaebacterial DNA polymerase


Yanxiang Zhao, David Jeruzalmi, Ismail Moarefi, Lore Leighton, Roger Lasken and John Kuriyan

Structure 1999 Oct 15;7(10):1189-99

Crystal Structure of Hck in Complex with a Src Family-Selective Tyrosine Kinase Inhibitor


Thomas Schindler, Frank Sicheri, Alexander Pico, Aviv Gazit, Alexander Levitzki and John Kuriyan

Mol Cell. 1999 May;3(5):639-48

Crystal Structure of the Cytoplasmic Domain of the Type I TGFß Receptor in Complex with FKBP12


Morgan Huse, Ye-Guang Chen, Joan Massagué and John Kuriyan

Cell 1999 Feb 5;96(3):425-36

1998

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin alpha


Elena Conti, Marc Uy, Lore Leighton, Günter Blobel and John Kuriyan

Cell 1998 Jul 24;94(2):193-204

Structure of Ras complexed with the Ras exchange factor region of the Son of Sevenless protein


Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J.

Nature 1998 Jul 23;394(6691):337-43

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein


Soisson, S. M., Nimnual, A. S., Uy, M., Bar-Sagi, D., and Kuriyan, J.

Cell 1998 Oct 16;95(2):259-68

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA


Xiaomin Chen, Uwe Vinkemeier, Yanxiang Zhao, David Jeruzalmi, James E. Darnell, Jr. and John Kuriyan

Cell 1998 May 29;93(5):827-39

1997

Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III


Guenther, B. D., Onrust, R., Sali, A., O'Donnell, M. and Kuriyan, J.

Cell 1997 Oct 31;91(3):335-45

Crystal Structure of the Src-family tyrosine kinase Hck


Sicheri, F., Moarefi, I. and Kuriyan, J.

Nature 1997 Feb 13;385(6617):602-9

Activation of the Src family tyrosine kinase Hck by SH3 domain displacement


Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J. and Miller, W.T.

Nature 1997 Feb 13;385(6617):650-3

1996

Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA


Gulbis, J., Kelman, Z., Gibbs, E., Hurwitz, J., O'Donnell, M. and Kuriyan, J.

Cell 1996 Oct 18;87(2):297-306

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain


Lee, C. H., Saksela, K., Mirza, U. A., Chait, B. T., and Kuriyan, J.

Cell 1996 Jun 14;85(6):931-42

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I


J. Goldberg, A. Nairn and J. Kuriyan

Cell 1996 Mar 22;84(6):875-87

1995

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1


Goldberg, J., H.-b. Huang, Y.-g. Kwon, P. Greengard, A.C. Nairn, and J. Kuriyan

Nature 1995 Aug 31;376(6543):745-53

1994

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA


Krishna TS, Kong XP, Gary S, Burgers PM and Kuriyan J.

Cell 1994 Dec 30;79(7):1233-43

1992

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides


G. Waksman, D. Kominos, S.R. Robertson, N. Pant, D. Baltimore, R.B. Birge, D. Cowburn, H. Hanafusa, B.J. Mayer, M. Overduin, M.D. Resh, C.B. Rios, L. Silverman and J. Kuriya.

Nature 1992 Aug 20;358(6388):646-53

Three-dimensional structure of the beta subunit of E. coli DNA Polymerase III Holoenzyme: a sliding DNA clamp


X.-P. Kong, R. Onrust, M.J. O'Donnell and J. Kuriyan

Cell 1992 May 1;69(3):425-37