HHMI UC Berkeley

Our laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction.

We use X-ray crystallography to determine the three-dimensional structures of proteins involved in signaling, as well as biochemical, biophysical, and computational analyses to figure out how they work.

A major focus in the laboratory is understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals.

In addition to studying signaling proteins, the laboratory has made fundamental contributions to understanding the structural basis for high-speed DNA replication.