Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
Kuriyan Lab, UC Berkeley

    Our laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication.
    We use x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to figure out how they work.
    A major focus in the laboratory is understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals.

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KURIYAN LAB
UNIVERSITY OF CALIFORNIA, BERKELEY
176 STANLEY HALL, QB3
BERKELEY, CA 94720-3220
TELEPHONE: 510 643 1710

   


 

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