Our laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication.
We use x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to figure out how they work.
A major focus in the laboratory is understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals.
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