Research in Progress
Publications from the lab
Search PubMed for "Kuriyan, J"
John Kuriyan's Page at HHMI
Research Publications and Associated Information
2013
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Older & Misc.
2013
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
2011
How a DNA polymerase clamp loader opens a sliding clamp.
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme
The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2
2010
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Analysis of the role of PCNA-DNA contacts during clamp loading
2009
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response
The tyrosine kinase Csk dimerizes through its SH3 domain
Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex
Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1
2008
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Membrane-dependent signal integration by the Ras activator Son of sevenless
Structural Basis for the Recognition of c-Src by Its Inactivator Csk
2007
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty
2006
Protein-protein Interactions in the Allosteric Regulation of Protein Kinases
A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless
Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III
A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain
Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium
2005
Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases
Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless
Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen
Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex
2004
Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex.
Fluorescence Measurements on the E. Coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding
Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex
2003
Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless
Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II
Structural evidence for feedback activation by Ras·GTP of the Ras-specific nucleotide exchange factor SOS
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Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit
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Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
A Reinterpretation of the Dimerization Interface of the N-terminal Domains of STATs
2002
Crystal Structures of the Kinase Domain of c-Abl
in Complex with the Small Molecule Inhibitors PD173955 and STI571
2001
TGF-beta Receptor Phosphorylation
Control
